ea0026p486 | Thyroid cancer | ECE2011
Filieri C
, Zatelli M C
, Minoia M
, Tagliati F
, Buratto M
, Ambrosio M R
, Pelizzo M
, degli Uberti E C
It has been demonstrated that everolimus, an mTOR inhibitor, has potent anti-proliferative effect in a human Medullary Thyroid Carcinoma (MTC) cell line, TT, and in two human MTC primary cultures. We aimed at evaluating the possible antiproliferative effects of everolimus in a group of 20 human MTC in primary culture. To this purpose, 20 MTCs were dispersed in primary cultures, treated without or with 1 nM 1 μM everolimus, 10 nM SOM230, and/or 50 nM IGF1. Cell viab...